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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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II. MEDICINAL CHEMISTRY OF NUCLEOSIDES/NUCLEOTIDES

Synthesis and Biological Activities of 2′-Modified 4′-Thionucleosides

Yuichi Yoshimura R & D Division, Yamasa Corporation, 2-10-1 Araoicho, Choshi, Chiba, 288, Japan
,
Kenji Kitano R & D Division, Yamasa Corporation, 2-10-1 Araoicho, Choshi, Chiba, 288, Japan
,
Mikari Watanabe R & D Division, Yamasa Corporation, 2-10-1 Araoicho, Choshi, Chiba, 288, Japan
,
Hiroshi Satoh R & D Division, Yamasa Corporation, 2-10-1 Araoicho, Choshi, Chiba, 288, Japan
,
Shinji Sakata R & D Division, Yamasa Corporation, 2-10-1 Araoicho, Choshi, Chiba, 288, Japan
,
Shinji Miura R & D Division, Yamasa Corporation, 2-10-1 Araoicho, Choshi, Chiba, 288, Japan
,
Noriyuki Ashida R & D Division, Yamasa Corporation, 2-10-1 Araoicho, Choshi, Chiba, 288, Japan
,
Haruhiko Machida R & D Division, Yamasa Corporation, 2-10-1 Araoicho, Choshi, Chiba, 288, Japan
&
Akira Matsuda Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, 060, Japan
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Pages 1103-1106 | Published online: 16 Aug 2006
 
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Abstract

We have synthesized 4′-thioDMDC, 4′-thiogemcitabine, and 4′-thioarabinonucleosides, as potential antitumor and antiviral agents, originated from D-glucose. Biological activities of these compounds are also described.

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