Addition of 2,3-Dihydrofuran to N₂-Acetyl-8-bromoguanine

M. Madre Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia

R. Zhuk Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia

G.-J. Koomen Lab. of Organic Chemistry, University of Amsterdam, 10018, WS, Amsterdam, the Netherlands

Abstract

N₂-Acetyl-8-bromoguanine has been found to react readily with 2,3-dihydrofuran in DMF in the presence of acid catalyst at room temperature to give 9-(tetrahydrofuryl-2)-8-bromo-N₂-acetylguanine in high yield. The structures of this compound and its deacetylated derivative were assigned by H and C NMR spectroscopy.

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Addition of 2,3-Dihydrofuran to N₂-Acetyl-8-bromoguanine

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Addition of 2,3-Dihydrofuran to N2-Acetyl-8-bromoguanine

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Addition of 2,3-Dihydrofuran to N₂-Acetyl-8-bromoguanine