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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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III. PRECLINICAL STUDIES OF OLIGOMERS

Modification of a Phosphorothioate Oligonucleotide with Cholesterol Induces Association of the Oligonucleotide to Serum Lipoproteins and Affects Its Biological Fate

Martin K. Bijsterbosch Biopharmaceutics Division LACDR, P.O. Box 9503, 2300, RA, Leiden, The Netherlands
,
Muthiah Manoharan ISIS Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, Ca, 92008, U.S.A.
,
Kathleen L. Tivel ISIS Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, Ca, 92008, U.S.A.
,
Erik T. Rump Biopharmaceutics Division LACDR, P.O. Box 9503, 2300, RA, Leiden, The Netherlands
,
Erik A.L. Biessen Biopharmaceutics Division LACDR, P.O. Box 9503, 2300, RA, Leiden, The Netherlands
,
Remco L.A. De Vrueh Biopharmaceutics Division LACDR, P.O. Box 9503, 2300, RA, Leiden, The Netherlands
,
P. Dan Cook ISIS Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, Ca, 92008, U.S.A.
&
Theo J.C. van Berkel Biopharmaceutics Division LACDR, P.O. Box 9503, 2300, RA, Leiden, The Netherlands
 show all
Pages 1165-1168 | Published online: 16 Aug 2006
 
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Abstract

A cholesterol-conjugated phosphorothioate ICAM-1 antisense oligo-nucleotide was evaluated for its binding to lipoproteins and its biodistribution. Our study indicates that the conjugate behaves differently from the parent compound.

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