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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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III. PRECLINICAL STUDIES OF OLIGOMERS

Synthesis of 3′,5′-Dithymidylyl-α-hydroxyphosphonate Dimer Building Blocks for Oligonucleotide Synthesis—A New Pro-oliguncleotide

Ralf P. Mauritz Institute of Organic Chemistry, Johann Wolfgang Goethe-University, Marie-Curie-Str. 11, D-60439, Frankfurt am Main, Germany
,
Chris Meier Institute of Organic Chemistry, Johann Wolfgang Goethe-University, Marie-Curie-Str. 11, D-60439, Frankfurt am Main, Germany
&
Eugen Uhlmann Hoechst AG, General Pharma Research G838, D-65926, Frankfurt am Main, Germany
Pages 1209-1212 | Published online: 16 Aug 2006
 
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Abstract

The synthesis of the dimer building blocks 1 and 2 and their introduction into (T)15-oligonucleotides is described. The stability against 3′-exonuclease digestion (SVP) as well as the hybridization properties (Tm values) were examined.

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