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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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III. PRECLINICAL STUDIES OF OLIGOMERS

Targeting HIV mRNA for Degradation: 2,5-A Antisense Chimeras as Potential Chemotherapeutic Agents for AIDS

Mark R. Player National Institutes of Health, National Institutes of Diabetes, Digestive and Kidney Diseases, 9000 Rockville Pk., Bethesda, MD, 20892-0805
,
Ratan Maitra Cleveland Clinic Research Foundation, 9500 Euclid Ave., Cleveland, OH, 44195-5001
,
Robert Silverman Cleveland Clinic Research Foundation, 9500 Euclid Ave., Cleveland, OH, 44195-5001
&
Paul F. Torrence National Institutes of Health, National Institutes of Diabetes, Digestive and Kidney Diseases, 9000 Rockville Pk., Bethesda, MD, 20892-0805
Pages 1221-1222 | Published online: 16 Aug 2006
 
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Abstract

We have identified a region within a 1 kb HIV gag RNA which can be ablated in vitro using a 2,5-A antisense chimera. The cleavage was specific and almost complete at a concentration of 100 nM chimera.

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