Resistance Profile of a Novel 2′, 3′ - Dideoxynucleoside Analog with Activity Against HIV-1

Nathalie Richard McGill University AIDS Centre, Jewish General Hospital, 3755 Cote Ste-Catherine Road, Montreal, Quebec, CANADA, H3R 1E2

Antonietta R. Belmonte McGill University AIDS Centre, Jewish General Hospital, 3755 Cote Ste-Catherine Road, Montreal, Quebec, CANADA, H3R 1E2

Horacio Salomon McGill University AIDS Centre, Jewish General Hospital, 3755 Cote Ste-Catherine Road, Montreal, Quebec, CANADA, H3R 1E2

Kazushige Nagai McGill University AIDS Centre, Jewish General Hospital, 3755 Cote Ste-Catherine Road, Montreal, Quebec, CANADA, H3R 1E2

Tarek Mansour BioChem Therapeutic Inc., 275 Armand-Frappier Boulevard, Laval, Quebec, CANADA, H7V 4A7

Mark A. Wainberg McGill University AIDS Centre, Jewish General Hospital, 3755 Cote Ste-Catherine Road, Montreal, Quebec, CANADA, H3R 1E2

Abstract

We have selected for resistance against a novel compound, (+) dOTFC, using HIV-1 tissue culture replication assays. A novel D67G (asp gly) mutation in HIV-1 reverse transcriptase has been identified that confers about 5-fold resistance to this drug but not to other nucleoside and non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Resistance Profile of a Novel 2′, 3′ - Dideoxynucleoside Analog with Activity Against HIV-1

Information for

Open access

Opportunities

Help and information

Resistance Profile of a Novel 2′, 3′ - Dideoxynucleoside Analog with Activity Against HIV-1

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature