Characterization of GPI2A, a Potent Inhibitor of HIV-1 Gene Expression and Viral Replication

Michael I. Anazodo Manitoba Institute of Cell Biology, and Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, MB, R3E 0V9, CANADA; Genesys Pharma Inc., Winnipeg, MB, R3P 1P4, CANADA

Elena Duta Manitoba Institute of Cell Biology, and Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, MB, R3E 0V9, CANADA; Genesys Pharma Inc., Winnipeg, MB, R3P 1P4, CANADA

Horacio Salomon McGill AIDS Centre, 3755 Chemin Cote-Ste-Catherine Road, Montreal, Quebec, H3T 1E2, CANADA

Albert D. Friesen Genesys Pharma Inc., Winnipeg, MB, R3P 1P4, CANADA

Mark A. Wainberg McGill AIDS Centre, 3755 Chemin Cote-Ste-Catherine Road, Montreal, Quebec, H3T 1E2, CANADA

Jim A. Wright Manitoba Institute of Cell Biology, and Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, MB, R3E 0V9, CANADA

Abstract

Fully thioated antisense molecules are often cytotoxic and non-specitic in action. GPI2A is thioated at 7 base positions. GPI2A posses sequence-specific activity against HIV-1 gene expression and viral replication without sigdcant cytotoxicity. Partial thioation did not compromise its uptake, cellular distribution and nuclease resistance.

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Characterization of GPI2A, a Potent Inhibitor of HIV-1 Gene Expression and Viral Replication

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Characterization of GPI2A, a Potent Inhibitor of HIV-1 Gene Expression and Viral Replication

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