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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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IV. PRECLINICAL STUDIES OF NUCLEOSIDES AND NUCLEOTIDES

Suicide Gene Therapy for Intrinsically Drug Resistant Solid Tumors

J. Arly Nelson Departments of Experimental Pediatrics and Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030
,
Bih-Fang Pan Departments of Experimental Pediatrics and Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030
,
Frank C. Marini III Departments of Experimental Pediatrics and Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030
,
David Farquhar Departments of Experimental Pediatrics and Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030
&
Craig A. Mullen Departments of Experimental Pediatrics and Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030
Pages 1251-1259 | Published online: 16 Aug 2006
 
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Abstract

The failure of available anticancer drugs to cure the common human solid tumors is thought to be caused by their poor selective toxicity. As demonstrated herein, suicide gene therapy offers the potential to improve selective toxicity.

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