Comparison of the Inhlbitory Effects of 2-Chloro-2′-deoxyadenosine and 9-β-D-Arabinosyl-2-fluoro-adenine on Metabolism of Deoxyadenosine in Human Lymphocytes and Erythrocytes

Krystyna Fabianowska-Majewska Department of General Chemistry, Medical University of Lódź, Lindleya 6, Lódź, 90-131, Poland Phone: 48-42-322 347 Fax: 48-42-322 347

Dorota Wyczechowska Department of General Chemistry, Medical University of Lódź, Lindleya 6, Lódź, 90-131, Poland Phone: 48-42-322 347 Fax: 48-42-322 347

Abstract

The effect of 2-chloro-2′-deoxyadenosine and 9-β-D-arabinosyl-2-fluoro-adenine on metabolism of deoxyadenosine in human lymphocytes or erythrocytes was estimated. These drugs demonstrate different effects; 2CdA blocks both the dAdo phosphorylation and deamination (at 95% and 55%, respectively), while F-ara-A inhibits dAdo phosphorylation only at 40% and remains without effect on ADA activity.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Comparison of the Inhlbitory Effects of 2-Chloro-2′-deoxyadenosine and 9-β-D-Arabinosyl-2-fluoro-adenine on Metabolism of Deoxyadenosine in Human Lymphocytes and Erythrocytes

Information for

Open access

Opportunities

Help and information

Comparison of the Inhlbitory Effects of 2-Chloro-2′-deoxyadenosine and 9-β-D-Arabinosyl-2-fluoro-adenine on Metabolism of Deoxyadenosine in Human Lymphocytes and Erythrocytes

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature