Synergistic Combinations of Nucleoside Analog Drugs with Other Drugs Induce Greater Apoptosis in Human Leukemic T-Cells

Partha Nandy Div. of Hem/Onc and Dept. of Pediatrics, School of Medicine, University of Southern California, Childrens Hospital, Los Angeles, CA, 90027

Antonia P. Periclou Div. of Hem/Onc and Dept. of Pediatrics, School of Medicine, University of Southern California, Childrens Hospital, Los Angeles, CA, 90027

Vassilios I. Avramis Div. of Hem/Onc and Dept. of Pediatrics, School of Medicine, University of Southern California, Childrens Hospital, Los Angeles, CA, 90027

Abstract

Combinations of nucleoside analog drugs such as 6-MP. ara-C. or F-araA are synergistic against human leukemic T-cells and induce apoptotic cell death. Addition of Taxotere or PEG-ASNase to the synergistic combination of nucleoside analog drugs augments the synergism several fold by enhancing cellular apoptosis.

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Synergistic Combinations of Nucleoside Analog Drugs with Other Drugs Induce Greater Apoptosis in Human Leukemic T-Cells

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Synergistic Combinations of Nucleoside Analog Drugs with Other Drugs Induce Greater Apoptosis in Human Leukemic T-Cells

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