Antileukemic Activities and Mechanism of Action of 2′-Deoxy-4′-methylcytidine and Related Nucleosides

Toyofumi Yamaguchi Department of Biological Sciences, Teikyo University of Science and Technology, Uenohara, Yamanashi, 409-01

Aki Tomikawa Department of Biological Sciences, Teikyo University of Science and Technology, Uenohara, Yamanashi, 409-01

Toshiaki Hirai Department of Biological Sciences, Teikyo University of Science and Technology, Uenohara, Yamanashi, 409-01

Takeo Kawaguchi Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, 350-02

Hiroshi Ohrui Faculty of Agriculture, Tohoku University, Sendai, 981, Japan

Mineo Saneyoshi Department of Biological Sciences, Teikyo University of Science and Technology, Uenohara, Yamanashi, 409-01

Abstract

Antileukemic activity of several analogues containing 2′-deoxy-4′-methylcytidine and its araC counterpart were evaluated against murine leukemic P388 cells in vitro and in vivo. Both compounds showed significant cytostatic activity (both IC₅₀=0.4 μM) in vitro and the former compound administered intraperitoneally at a dose of 3 mg/kg/day × 5 showed high activity (T/C=175%) in vivo. The mechanism of action of these 5′-triphosphates on DNA polymerases in detail will be also described.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Antileukemic Activities and Mechanism of Action of 2′-Deoxy-4′-methylcytidine and Related Nucleosides

Information for

Open access

Opportunities

Help and information

Antileukemic Activities and Mechanism of Action of 2′-Deoxy-4′-methylcytidine and Related Nucleosides

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature