Synthesis and Biological Activity of New 2′ 5′-Oligonucleotides

Evgeny I. Kvasyuk Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, 220141, Belarus

Tamara I. Kulak Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, 220141, Belarus

Igor A. Mikhailopulo Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, 220141, Belarus

Robert J. Suhadolnik Department of Biochemistry, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 19140, USA

Earl E. Henderson Department of Microbiology and Immunology, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 19140, USA

Susan E. Horvath Department of Biochemistry, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 19140, USA

Ming-Xu Guan Department of Microbiology and Immunology, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 19140, USA

Wolfgang Pfleiderer Fakultät für Chemie, Universität Konstanz, Postfach 5560, D-78434, Konstanz

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Abstract

Some new 2′,5′-oligonucleotide trimers containing the antiviral nucleoside ribavirin and the cytokine 6-benzylaminopurine riboside in different position of the oligos have been synthesized. Some of the trimers showed biological inhibitions of HIV-1 reverse transcriptase, HIV-1 induced syncytia formation and activation of RNase L.

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Synthesis and Biological Activity of New 2′ 5′-Oligonucleotides

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Synthesis and Biological Activity of New 2′ 5′-Oligonucleotides

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