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V. NOVEL NUCLEOSIDES AND OLIGOMERS

Sequence-Specific Cleavage of RNA Using Macrocyclic Lanthanide Complexes Conjugated to Oligonucleotides: A Structure Activity Study

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Pages 1357-1368 | Published online: 16 Aug 2006
 

Abstract

A series of lanthanide complexes were synthesized and conjugated to an oligodeoxynucleotide. Sequence-specific cleavage of a complementary RNA by the conjugates was performed and results are discussed in terms of structure of the complexes.

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