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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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V. NOVEL NUCLEOSIDES AND OLIGOMERS

Synthesis and IMP Dehydrogenase (Type I and Type II) Inhibitory Activity of Isosteric NAD Analogs Derived from Thiophenfurin and Furanfurin

P. Franchetti Dipartimento di Scienze Chimiche, Università di Camerino, 62032, Camerino, Italy
,
L. Cappellacci Dipartimento di Scienze Chimiche, Università di Camerino, 62032, Camerino, Italy
,
G. Abu Sheikha Dipartimento di Scienze Chimiche, Università di Camerino, 62032, Camerino, Italy
,
H. N. Jayaram Laboratory for Experimental Oncology, Indiana University School of Medicine, Indianapolis, Indiana, 46202, U.S.A.
,
B. P. Schneider Laboratory for Experimental Oncology, Indiana University School of Medicine, Indianapolis, Indiana, 46202, U.S.A.
,
T. Sint Laboratory for Experimental Oncology, Indiana University School of Medicine, Indianapolis, Indiana, 46202, U.S.A.
,
V. V. Gurudutt Laboratory for Experimental Oncology, Indiana University School of Medicine, Indianapolis, Indiana, 46202, U.S.A.
,
F. R. Collart Argonne National Laboratory, Argonne, IL, 60439, USA
,
E. Hubeman Argonne National Laboratory, Argonne, IL, 60439, USA
&
M. Grifantini Dipartimento di Scienze Chimiche, Università di Camerino, 62032, Camerino, Italy
 show all
Pages 1415-1418 | Published online: 16 Aug 2006
 
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Abstract

Thiophene-3-carboxamide adenine dinucleotide (TFAD), and furan-3-carboxamide adenine dinucleotide (FFAD), two NAD analogs, were synthesized and evaluated as inhibitors of inosine monophosphate dehydrogenase type I and type II.

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