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Abstract
A series of o ne t wo c arbonucleoside (OTC) analogues of thymine was synthetized and their conformation was studied by AM1 theoretical calculations. The low-energy conformations of Compound 1 and 2′,3′-dideoxythymidine, showed a degree of steric congruity.
Notes
All compounds were purified by FC using 98:2 methylene chloride/methanol as eluant and had spectral and analytical data consistent with their structures
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