2′-C-Alkylribonucleosides: Design, Synthesis, and Conformation

Abstract

Certain 2′-C-alkylribonucleotides have been designed as potential mechanism-based inactivators of ribonucleotide reductases. A short, flexible route toward the corresponding nucleosides and NMR evidence concerning their preferred solution conformations are discussed.

Notes

A full account of this synthetic methodology is in preparation

This work was supported by Grant #IN-176-D from the American Cancer Society and through the American Association of Colleges of Pharmacy Grant Program for New Investigators.