The Synthesis of 2′-C-Functionalised Nucleosides for Incorporation into Catalytic RNA

Anthony J. Lawrence Robert Robinson Labs., Dept. of Chemistry, University of Liverpool, P. O. Box 147, Liverpool, L69 3BX, U. K.

John B. J. Pavey Robert Robinson Labs., Dept. of Chemistry, University of Liverpool, P. O. Box 147, Liverpool, L69 3BX, U. K.

Ian A. O'Neil Robert Robinson Labs., Dept. of Chemistry, University of Liverpool, P. O. Box 147, Liverpool, L69 3BX, U. K.

Richard Cosstick Robert Robinson Labs., Dept. of Chemistry, University of Liverpool, P. O. Box 147, Liverpool, L69 3BX, U. K.

Abstract

Five 2′-C-functionalized nucleosides (1–5) have been prepared and incorporated into dinucleoside monophosphates. The effect of the functionality on the stability of the adjacent phosphodiester bond toward hydrolysis by nuclease enzymes and extremes of pH has been assessed.

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The Synthesis of 2′-C-Functionalised Nucleosides for Incorporation into Catalytic RNA

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The Synthesis of 2′-C-Functionalised Nucleosides for Incorporation into Catalytic RNA

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