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Abstract
Oligonucleotides containing novel phoshoramidite 12 were synthesized and studied for their hybridization properties for the first time. Interestingly, these modified oligonucleotides showed a remarkable resistance to exonuclease.
Notes
Nucleobases attached to serinol via acetamide linker. See Fig. 1 and structure (2)
All the compounds synthesized were confirmed by 1HNMR and elemental analysis
Oligonucleotides were digested with a mixture of spleen phosphodiesterase, snake venom phosphodiesterase, and bacterial alkaline phosphatase to provide individual nucleosides which were analyzed by HPLC
