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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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V. NOVEL NUCLEOSIDES AND OLIGOMERS

Oligonucleotides Containing Consecutive 2′-Deoxy-Isoguanosine Residues: Synthesis, Parallel Duplex Formation and Identification of a d(T4iG4T4) Tetraplex

Frank Seela Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Barbarastr. 7, D-49069, Osnabrück, Germany
,
Changfu Wei Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Barbarastr. 7, D-49069, Osnabrück, Germany
&
Alexander Melenewski Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Barbarastr. 7, D-49069, Osnabrück, Germany
Pages 1523-1527 | Published online: 16 Aug 2006
 
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Abstract

Oligonucleotides containing consecutive 2′-deoxyisoguano-sines were synthesized by using building blocks protected with a diphenylcarb-amoyl residue. Parallel duplexes were formed by iGd-dC base pairs and a tetraplex of d(T4iG4T4) was identified by ion exchange HPLC.

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Related Research Data

Identification and quantification of isoguanosine in humans and mice.
Source: Informa UK Limited
Self-Assembled Ionophores from Isoguanosine
Source: American Chemical Society (ACS)
PYRANOSYL-RNA ('P-RNA') : BASE-PAIRING SELECTIVITY AND POTENTIAL TO REPLICATE
Source: Wiley
2'-Deoxyisoguanosine: Synthesis and incorporation into oligodeoxyribonucleotides
Source: Institute of Organic Chemistry & Biochemistry
Diphenylcarbamoyl and propionyl groups: a new combination of protecting groups for the guanine residue
Source: Elsevier BV
Substituent Reactivity and Tautomerism of Isoguanosine and Related Nucleosides
Source: Wiley

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