Mini-antisense Oligonucleotides

D. V. Pyshnyi Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of RAS, Novosibirsk, 630090, Russia

I. A. Pyshnaya Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of RAS, Novosibirsk, 630090, Russia

S. G. Lokhov Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of RAS, Novosibirsk, 630090, Russia

E. M. Ivanova Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of RAS, Novosibirsk, 630090, Russia

V. F. Zarytova Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of RAS, Novosibirsk, 630090, Russia

Abstract

A new strategy of selective DNA target modification was proposed. The using of reactive derivatives of short oligonucleotides in the presence of flanking effector pair allows one to modify DNA target only when the perfect complementary complex of DNA target and oligonucleotide tandem is formed.

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Mini-antisense Oligonucleotides

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Mini-antisense Oligonucleotides

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