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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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VI. CHEMICAL DEVELOPMENT AND ANALYTICAL CHEMISTRY

Structural Correlations of Backbone Modifications in Antisense Oligonucleotide Duplexes

Xiaolian Gao Department of Chemistry, University of Houston, Houston, TX, 77204-5641
,
Jeffrey S. Rice Sealy Center for Structural Biology, Dept. of Human Biological chemistry and Genetics, University of Texas Medical Branch, Galveston, TX, 77555-1157
,
Collin W. Cross Department of Chemistry, University of Houston, Houston, TX, 77204-5641
&
Xueyong Yang Department of Chemistry, University of Houston, Houston, TX, 77204-5641
Pages 1599-1608 | Published online: 16 Aug 2006
 
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Abstract

This article presents a collective of structural analyses concerning backbone modified oligonucleotides and various factors which correlate the conformational preference of backbone modifications with the stability of antisense duplexes.

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