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VI. CHEMICAL DEVELOPMENT AND ANALYTICAL CHEMISTRY

Phthaloyl Strategy—A New Approach Towards Oligodeoxyribonucleotide Synthesis

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Pages 1621-1624 | Published online: 16 Aug 2006
 

Abstract

A new rapid strategy for machine-aided oligodeoxyribonucleotide synthesis has been established utilizing phthaloyl groups for protection of the heterocyclic amino functions within the phosphoramidite approach. A large number of DNA-sequences has been synthesized. Due to high purity and speed of performance this strategy offers an excellent alternative to the common used acyl approach.

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