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The ability of (A,G)- and (G,T)-oligonucleotides to form triple-helices with a critical polypurine-polypyrimidine sequence of the c-Ki-ras promoter has been examined, together with their capacity to inhibit the expression of the chloramphenicol acetyl-transferase gene driven by the c-Ki-ras promoter in a transfected cellular system.
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