Pharmacologic Disposition of a Phosphorothioate Oligodeoxynucleotide in Mice

Abstract

G3139, an 18mer phosphorothioate (S-labeled), was administered to mice by single i.v. bolus or continuous S.C. infusion. The latter schedule resulted in reduced liver metabolism and urinary excretion together with greater tissue accumulation, in particular to the liver, kidney and bone marrow, probably reflecting the dose received.