Inhibition of Tumor Necrosis Factor Alpha (TNFα) Expression and Function In Vitro by Modified Antisense Oligonucleotides

Joshua O. Ojwang Aronex Pharmaceuticals, Inc., 9391 Grogans Mill Road, The Woodlands, TX, 77380, USA

T. Sudhakar Rao Aronex Pharmaceuticals, Inc., 9391 Grogans Mill Road, The Woodlands, TX, 77380, USA

Hélène B. Marshall Aronex Pharmaceuticals, Inc., 9391 Grogans Mill Road, The Woodlands, TX, 77380, USA

Shawn D. Mustain Aronex Pharmaceuticals, Inc., 9391 Grogans Mill Road, The Woodlands, TX, 77380, USA

Nilabh Chaudhary Aronex Pharmaceuticals, Inc., 9391 Grogans Mill Road, The Woodlands, TX, 77380, USA

David A. Walker Aronex Pharmaceuticals, Inc., 9391 Grogans Mill Road, The Woodlands, TX, 77380, USA

Anusch Peyman Hoechst Marion Roussel, G838, D-65926, Frankfurt, Germany

Eugen Uhlmann Hoechst Marion Roussel, G838, D-65926, Frankfurt, Germany

Ganapathi R. Revankar Aronex Pharmaceuticals, Inc., 9391 Grogans Mill Road, The Woodlands, TX, 77380, USA

Robert F. Rando Aronex Pharmaceuticals, Inc., 9391 Grogans Mill Road, The Woodlands, TX, 77380, USA

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Abstract

Antisense oligonucleotides containing C-5 hexynyl/propynyl modified pyrimidines were synthesized using solid phase phosphoramidite chemistry. These modified oligonucleotides were found to have significant inhibitory activity against TNFα production in vitro.

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Inhibition of Tumor Necrosis Factor Alpha (TNFα) Expression and Function In Vitro by Modified Antisense Oligonucleotides

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Inhibition of Tumor Necrosis Factor Alpha (TNFα) Expression and Function In Vitro by Modified Antisense Oligonucleotides

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