Abstract
Prophylactic therapy with 5′-dCACGTTGAGGGGCAT phosphorothioate, (2.5 nmol/hr) strongly inhibited tumorigenesis in Eμ-myc transgenic mice, and ablated spleen cell MYC antigen. However, the anti-c-myc DNA also stimulated proliferation of spleen cells in vitro, though much less so than a positive CG motif control, 5′-dGCATGACGTTGAGCT.