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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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VII. BIOLOGICAL STUDIES OF OLIGOMERS

Inhibition of Respiratory Syncytial Virus by Double Termini-Protected 2–5A Antisense Chimeras

Wei Xiao Section on Biomedical Chemistry, NIDDK, National Institutes of Health, Bethesda, MD, 20892, USA
,
Guiying Li Section on Biomedical Chemistry, NIDDK, National Institutes of Health, Bethesda, MD, 20892, USA
,
Paul F. Torrence Section on Biomedical Chemistry, NIDDK, National Institutes of Health, Bethesda, MD, 20892, USA
,
Nick M. Cirino Department of Cancer, Biology Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, 44195, USA
&
Robert H Silverman Department of Cancer, Biology Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, 44195, USA
Pages 1735-1738 | Published online: 16 Aug 2006
 
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Abstract

Respiratory syncytial virus (RSV) replication was reduced by greater than 90% after treatment of infected human tracheal epithelial cell line, 9HTE, with double termini-protected 2–5 A antisense chimeras.

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