Oligonucleotide Conjugates Derived from an Electrophilic Site: Conjugation to Baseless Carbohydrate Residue. Synthesis, Hybridization and Modeling Studies

Abstract

Conjugation of electrophiles to oligonucleotides via tethers camying nucleophilic sites well-known. However, for the rever.se reaction, the availahlc methods to generate electrophilic sites in oligonucleotides are not many: (e.g., periodate oxidation of terminal rihose sugar followed by reductive amination).