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Nucleosides and Nucleotides Volume 16, 1997 - Issue 7-9
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VIII. SPECIAL TOPICS

Molecular Engine for Transporting Drugs Across Cell Membranes

James Summerton ANTIVIRALS Inc., 4575 S. W. Research Way, Suite 200, Corvallis, Oregon, 97333, USA
&
Dwight Weller ANTIVIRALS Inc., 4575 S. W. Research Way, Suite 200, Corvallis, Oregon, 97333, USA
Pages 1785-1788 | Published online: 16 Aug 2006
 
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Abstract

A molecular engine has been developed from first principles to transport drugs from endosomes to the cytosol of cells. The engine is powered by the pH differential across the endosomal membrane, does not disrupt the endosomal membrane, and is disassembled into innocuous components after carrying out its transport function.

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