Synthesis of Copper-64 and Technetium-99M Labeled Oligonucleotides with Macrocyclic Ligands

Sven Wagner German Cancer Research Center, Radiopharmaceutical Chemistry, D-69120, Heidelberg

Michael Eisenhut Department of Nuclear Medicine, Radiological University Clinic, D-69120, Heidelberg

Ramon Eritja EMBL, Meyerhofstrasse 1, Postfach 102209, D-69012, Heidelberg, Germany

Franz Oberdorfer German Cancer Research Center, Radiopharmaceutical Chemistry, D-69120, Heidelberg

Abstract

An efficient procedure for the preparation of oligonucleotides carrying a mono-N-substituted azamacrocycle and its radiolabeled complex with Cu-64 and Tc-99m is reported. The new derivatives are of potential interest for Positron Emission Tomography and Single Photon Emission Tomography.

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Synthesis of Copper-64 and Technetium-99M Labeled Oligonucleotides with Macrocyclic Ligands

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Synthesis of Copper-64 and Technetium-99M Labeled Oligonucleotides with Macrocyclic Ligands

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