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Original Articles

Concept of “Binary Oligonucleotide Reagent”

Pages 1969-1975 | Published online: 22 Aug 2006
 

Abstract

A new strategy for site-directed chemical modification of NA is described. NA-target-driven autoligation reaction between two oligonucleotide derivatives with N-(2-chloroethyl)-N-(p-formylphenyl)-N-propyl-N-3 -ydeneamino and 4-carbohydrazidephenyl groups at their opposing termini results in the NA-target modification, which is several times more effective than modification by one of the derivatives.

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