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Nucleosides and Nucleotides Volume 18, 1999 - Issue 9
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Original Articles

A Simple and Efficient Procedure for the Synthesis of an Alendronate- Oligonucleotide Conjugate via a Carbamate Linker

Lecouvey M. Laboratoire de Chimie Structurale, et Spectroscopie Biomoléculaire (UPRESA 7031-CNRS), UFR S.M.B.H. Université Paris-Nord. 74, Rue Marcel Cachin, 93017, BOBIGNY Cedex, FRANCE
,
Dufau C. Laboratoire de Chimie Structurale, et Spectroscopie Biomoléculaire (UPRESA 7031-CNRS), UFR S.M.B.H. Université Paris-Nord. 74, Rue Marcel Cachin, 93017, BOBIGNY Cedex, FRANCE
,
El Manouni D. Laboratoire de Chimie Structurale, et Spectroscopie Biomoléculaire (UPRESA 7031-CNRS), UFR S.M.B.H. Université Paris-Nord. 74, Rue Marcel Cachin, 93017, BOBIGNY Cedex, FRANCE
&
Leroux Y. Laboratoire de Chimie Structurale, et Spectroscopie Biomoléculaire (UPRESA 7031-CNRS), UFR S.M.B.H. Université Paris-Nord. 74, Rue Marcel Cachin, 93017, BOBIGNY Cedex, FRANCE
Pages 2109-2120 | Received 09 Feb 1999, Accepted 16 Jun 1999, Published online: 04 Oct 2006
 
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Abstract

In order to combine the biological properties of oligonucleotides, a synthetic chemical modelized reaction was performed and the procedure then applied to the preparation of an alendronate-deoxyoligonucleotide conjugate through a carbamate linker.

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