Over-Expression of COX-2 Induces Human Ovarian Cancer Cells (CAOV-3) Viability, Migration and Proliferation in Association with PI3-k/Akt Activation

Pingqing Gu Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Nanjing, P.R. of China

Yajuan Su Clinical Laboratory, Southern Medical University, Guangzhou, P.R. of China

Shuyu Guo Clinical Laboratory, Southern Medical University, Guangzhou, P.R. of China

Lichen Teng Clinical Laboratory, Southern Medical University, Guangzhou, P.R. of China

Ye Xu Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Nanjing, P.R. of China

Juan Qi Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Nanjing, P.R. of China

Hui Gong Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Nanjing, P.R. of China

Youqun Cai Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Nanjing, P.R. of China

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Abstract

COX-2 is involved in several pathological processes. The action of COX-2 on human ovarian cancer cell line (CAOV-3) and relative signal pathway has not been demonstrated. We explored the effects of COX-2 on the CAOV-3 viability and migration, moreover the proliferation of CAOV-3, and then ascertained the roles of PI3-k/Akt in these processes. The results showed that COX-2 increased the cells viability, migration and augment the number of CAOV-3. LY294002 could reduce COX-2 induce cells viability, migration and proliferation. These data indicate that COX-2 induce cells viability and migration, moreover promote the proliferation of CAOV-3 via PI3-k/Akt signal pathway.

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Over-Expression of COX-2 Induces Human Ovarian Cancer Cells (CAOV-3) Viability, Migration and Proliferation in Association with PI3-k/Akt Activation

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Over-Expression of COX-2 Induces Human Ovarian Cancer Cells (CAOV-3) Viability, Migration and Proliferation in Association with PI3-k/Akt Activation

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