125
Views
17
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLECellular and Molecular Biology

Over-Expression of COX-2 Induces Human Ovarian Cancer Cells (CAOV-3) Viability, Migration and Proliferation in Association with PI3-k/Akt Activation

, , , , , , & show all
Pages 822-829 | Published online: 11 Jun 2009

REFERENCES

  • Lorusso D., Ferrandina G., Graggi S., Gadduci A., Pignata S., Tateo S., Bia-monte R., Manzione L., Di Vagno G., Ferrau F., Scambia G., Phase I II. multicenter randomized trial of amifostine as cytoprotect-ant in first-line chemotherapy in ovarian cancer patients. Ann Oncol 2003; 14: 1086–1093
  • Melichar B., Urbanek L., Krcmova L., Kalabova H., Svobodova I., Drag-ounova E., Vesely P., Hyspler R., Solichova D. Urinary neopterin in patients with ovarian cancer. Pteridines 2006; 17: 145–153
  • McGuire W. P., Hoskins W. J., Brady M. F., Kucera P. R., Partridge E. E., Look K. Y., Clarke-Pearson D. L., Davidson M. Cyclophosphamide and cis-platin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N Engl J Med 1996; 334: 1–6
  • Cok S. J., Acton S. J., Morrison A. R. The proximal region of the 3-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U. J Biol Chem 2003; 278: 36157–36162
  • Dixon D. A. Dysregulated post-transcriptional control of COX-2 gene expression in cancer. Curr Pharm Des 2004; 10: 635–646
  • Dixon D. A., Balch G. C., Kedersha N., Anderson P., Zimmerman G. A., Beauchamp R. D., Prescott S. M. Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. J Exp Med 2003; 198: 475–481
  • Dixon D. A., Tolley N. D., King P. H., Nabors L. B., McIntyre T. M., Zimmerman G. A., Prescott S. M. Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. J Clin Investig 2001; 108: 1657–1665
  • Mukhopadhyay D., Houchen C. W., Kennedy S., Dieckgraefe B. K., Anant S. Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2. Mol Cell 2003; 11: 113–126
  • Muller-Decker K., Neufang G., Berger I., Neumann M., Marks F., Furstenberger G. Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis. Proc Natl Acad Sci USA 2002; 99: 12483–12488
  • Oshima M., Dinchuk J. E., Kargman S. L., Oshima H., Hancock B., Kwong E., Trzaskos J. M., Evans J. F., Taketo M. M. Suppression of intestinal polyposis in Apc 716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 1996; 87: 803–809
  • Brunet A., Bonni A., Zigmond M. J., Lin M. Z., Juo P., Hu L. S., Anderson M. J., Arden K. C., Blenis J., Greenberg M. E. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96: 857–868
  • Gao L. J., Qiu W., Wang Y. W., Xu W. H., Xu J., Tong J. X. Sublytic Complement C5b-9 Complexes Induce Thrombospondin-1 Production in Rat Glomerular Mesangial cells via PI3-k/Akt: Association with Activation of latent Transforming Growth Factor-β1. Clin Exp Immu 2006; 144: 326–334
  • Roymans D., Slegers H. Phosphoinositide 3-kinase in tumor progression. Eur J Biochem 2001; 268: 487–498
  • Shimamura H., Terada Y., Okado T., Tanaka H., Inoshita S., Sasaki S. The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-κB and Bad. J Am Soc Nephrol 2003; 14: 1427–1434
  • Simon A. R., Vikis H. G., Stewart S., Fanburg B. L., Cochran B. H. Regulation of Stat3 by direct binding to the Rac1 GTPase. Science 2000; 290: 144–147
  • Stofega M. R., Argetsinger L. S., Wang H., Ullrich A., Carter-Su C. Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha. J Biol Chem 2000; 275: 28222–28229
  • Jemal A., Murray T., Ward E., Samuels A., Tiwari R. C., Ghafoor A., Feuer E J., Thun M. J. Cancer Statistics, 2005. CA Cancer J Clin, 55(1)10–30
  • Kawamori T., Wakabayashi K. COX-2 and prostanoid receptors: good targets for chemoprevention. J Environ Pathol Toxicol Oncol 2002; 21(2)149–153
  • Hanif R., Pittas A., Feng Y., Koutsos M. I., Qiao L., Staiano-Coico L., Shiff S. I., Rigas B. Effects of nonsteroidal anti-infl amatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem Pharmacol 1996; 52: 237–245
  • Yu H. P., Shi L. Y., Lu W. H., Su Y. H., Li Y. Y., Xu S. Q. Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398. J Gastroenterol Hepatol 2004; 19: 638–642
  • Choi E. M., Kwak S. J., Kim Y. M., Ha K. S., Kim J. I., Lee S. W., Han J. A. COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells. Exp Mol Med 2005; 37: 199–203
  • Liu X. H., Yao S., Kirschenbaum A., Levine A. C. NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells. Cancer Res 1998; 58: 4245–4249
  • Hida T., Leyton J., Makheja A. N., Ben-Av P., Hla T., Martinez A., Mulshine J., Malkani S., Chung P., Moody T. W. Non-small cell lung cancer cycloxygenase activity and proliferation are inhibited by non-steroidal antiinfl ammatory drugs. Anticancer Res 1998; 18: 775–782
  • Kim S. H., Song S. H., Kim S. G., Chun K. S., Lim S. Y., Na H. K., Kim J. W., Surh Y. J., Bang Y. J., Song Y. S. Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NFkappaB as a possible target. J Cancer Res Clin Oncol 2004; 130: 551–560
  • Shimamura H., Terada Y., Okado T., Tanaka H., Inoshita S., Sasaki S. The Pi3-Kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-κB and Bad. J Am Soc Nephrol 2003; 14: 1427–1434

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.