Glyoxalase I Glu111Ala Polymorphism in Patients with Breast Cancer

Alexandra Germanová Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

Anna Germanová Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

Petra Tesarová Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

Marie Jáchymová Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

Karel Zvára EuroMISE Center of Charles University and Academy of Sciences CR, Institute of Computer Science AS CR, Prague, Czech Republic

Tomáš Zima Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

Marta Kalousová Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

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Abstract

Effect of advanced glycation end products (AGEs) in the pathogenesis of cancer could be diminished by interaction with soluble RAGE or by reducing AGE-precursors via glyoxalase I. Glu111Ala polymorphism of glyoxalase I gene, AGEs, and sRAGE serum levels were studied in 113 breast cancer patients and in 58 controls. Higher frequency of the mutated C allele was found in patients with negative estrogen receptors and in patients in clinical stage III compared to controls (P< 0.05). The presence of the C allele could represent a negative prognostic factor; however, further studies are needed to confirm this hypothesis.

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Glyoxalase I Glu111Ala Polymorphism in Patients with Breast Cancer

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Glyoxalase I Glu111Ala Polymorphism in Patients with Breast Cancer

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