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Original Articles

Variability Analysis of HIV-1 gp120 V3 Region: I. Point Estimators for the Amino Acid Distribution Characteristics

, , , , &
Pages 217-229 | Received 03 Jul 1997, Published online: 21 May 2012
 

Abstract

Enumerating procedure for symbol sequences is proposed. Relationship between Hamming distance for symbol sequences and Euclidean distance for corresponding enumerations is established, and more universal Hamming-transformed Euclidean measure is constructed. A distribution function of amino acid substitutions and some of its point estimators (consensus, subconsensus, sample mean, sample central moments and asymmetry coefficient) are introduced. Hamming-transformed Euclidean measures between consensuses, subconsensuses and sample means for ten HIV-1 taxons of gp120 V3 regions are calculated. It is demonstrated that these taxons have a complicated pattern which is significant for their classification.

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