Abstract
Intrinsically disordered proteins are involved in a range of functional roles in the cell, as well as being associated with a number of diverse diseases, including cancers, neurodegenerative disorders, and cardiac myopathies. We use single-molecule fluorescence approaches to characterize disordered proteins implicated in the progression of Parkinson’s and Alzheimer’s diseases. Our goal is to understand, how disease-associated modifications to these proteins alter their conformational and dynamic properties and to relate these changes to disease pathology.
This work is supported by NSF MCB 0919853.