Cell cycle control, DNA damage checkpoints and cancer

Marikki Laiho Haartman Institute, Molecular Cancer Biology Research Program, University of Helsinki and Helsinki University Central Hospital, FIN-00014 Helsinki, Finland

Leena Latonen Haartman Institute, Molecular Cancer Biology Research Program, University of Helsinki and Helsinki University Central Hospital, FIN-00014 Helsinki, Finland

Abstract

DNA damage checkpoints are essential control points in the cell cycle ensuring effective damage repair. The loss of checkpoint functions leads to loss of genomic integrity and allows accumulation of genetic damage in the daughter cells. Checkpoint deficiency is one of the main causes of DNA aberrations in cancer.

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Cell cycle control, DNA damage checkpoints and cancer

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Cell cycle control, DNA damage checkpoints and cancer

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