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Special Section: Molecular Diagnosis and Therapy of Cancer

Cell cycle control, DNA damage checkpoints and cancer

&
Pages 391-397 | Published online: 04 Apr 2013

References

  • Friedberg EC. How nucleotide excision repair protects against cancer.Nat Rev Cancer 2001; 1: 22–33.
  • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis.Cell 1990; 61: 759–67.
  • Hanahan D, Weinberg RA. The hallmarks of cancer.Cell 2000; 100: 57–70.
  • Hartwell LH, Weinert TA. Checkpoints: controls that ensure the order of cell cycle events.Science 1989; 246: 629–34.
  • Paulovich AG, Toczyski DP, Hartwell LH. When checkpoints fail.Cell 1997; 88: 315–21.
  • Hoeijmakers JHJ. Genome maintenance mechanisms for preventing cancer.Nature 2001; 411: 366–74.
  • Bartek J, Falck J, Lukas J. CHK2 kinase-a busy messenger.Nat Rev Mol Cell Biol 2001; 2: 877–86.
  • Gudkov AV, Komarova EA. The role of p53 in determining sensitivity to radiotherapy.Nat Rev Cancer 2003; 3: 117–29.
  • Eller MS, Ostrom K, Gilchrest BA. DNA damage enhances melanogenesis.Proc Natl Acad Sci USA \996\ 93: 1087-92.
  • Bender K, Blattner C, Knebel A, Iordanov M, Herrlich P, Rahmsdorf HJ. UV-induced signal transduction.J Pboto-cbem Pbotobiol B 199"; 3^: 1–17.
  • Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective.Nature 2000; 408: 433–9.
  • Gentile M, Latonen L, Laiho M. Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses.Nucl Acids R�2003; 31: in press.
  • Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, et al. Opposing effects of Ets and Id proteins on pl61NK4a expression during cellular senescence.Nature 2001; 409: 1067–70.
  • Lasorella A, Iavarone A, Israel MA. Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins.Mol Cell Biol 1996; 16: 2570–8.
  • Mantovani R. A survey of 178 NF-Y binding CCAAT boxes.Nucleic Acids Res 1998; 26: 1135–43.
  • Shiloh Y. ATM and related protein kinases: safeguarding genome integrity.Nat Rev Cancer 2003; 3: 155–68.
  • Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.Nature 2003; 421: 499–506.
  • Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. ATM phosphorylates histone H2AX in response to DNA double-strand breaks.J Biol Cbem 2001; 276: 42462–7.
  • Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.J Biol Cbem 2001; 276: 47759–62.
  • Iwabuchi K, Bartel PL, Li B, Marraccino R, Fields S. Two cellular proteins that bind to wild-type but not mutant p53.Proc Natl Acad Sci USA 1994; 91: 6098–102.
  • Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.Proc Natl Acad Sci USA 2000; 97: 10389–94.
  • Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chkl.Mol Cell Biol 2001; 21: 4129–39.
  • Lukas C, Bartkova J, Latella L, Falck J, Mailand N, Schroeder T, et al. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology.Cancer Res 2001; 61: 4990–3.
  • Levine AJ. p53, the cellular gatekeeper for growth and division.Cell 1997; 88: 323–31.
  • Zhao R, Gish K, Murphy M, Yin Y, Notterman D, Hoffman WH, et al. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays.Genes Dev 2000; 14: 981–93.
  • El-Deiry WS. Regulation of p53 downstream genes.Semin Cancer Biol 1998; 8: 345–57.
  • El-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J, et al. WAF1 CIP1 is induced in p53-mediated Gl arrest and apoptosis.Cancer Res 1994; 54: 1169–74.
  • Meek DW. Mechanisms of switching on p53: a role for covalent modification?Oncogene \999; 18: 7666-75.
  • Tibbetts RS, Brumbaugh KM, Williams JM, Sarkaria JN, Cliby WA, Shieh S-Y, et al. A role for ATR in the DNA damage-induced phosphorylation of p53.Genes Dev 1999; 13: 152–7.
  • Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage.Science 1998; 281: 1674–7.
  • Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.Science 1998; 281: 1677–9.
  • Chehab NH, Malikzay A, Appel M, Halazonetis TD. Chk2/hCdsl functions as a DNA damage checkpoint in G(l) by stabilizing p53.Genes Dev 2000; 14: 278–88.
  • Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases Chkl and Cdsl (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.Genes Dev 2000; 14: 289–300.
  • Lakin N, Jackson SP. Regulation of p53 in response to DNA damage.Oncogene 1999; 18: 7644–55.
  • Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2.Science 2000; 287: 1824–7.
  • Nilsson I, Hoffmann I. Cell cycle regulation by the Cdc25 phosphatase family.Prog Cell Cycle Res 2000; 4: 107–14.
  • Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.Nature 2001; 410: 842–7.
  • Mailand N, Falck J, Lukas C, Syljuasen RG, Welcker M, Bartek J, et al. Rapid destruction of human Cdc25A in response to DNA damage.Science 2000; 288: 1425–9.
  • Falck J, Petrini JH, Williams BR, Lukas J, Bartek J. The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways.Nat Genet 2002; 30: 290–4.
  • Zhao H, Watkins JL, Piwnica-Worms H. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.Proc Natl Acad Sci USA 2002;99: 14795–800.
  • Shimuta K, Nakajo N, Uto K, Hayano Y, Okazaki K, Sagata N. Chkl is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition. EMBOJ 2001; 21: 3694–703.
  • Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 53BP1, a mediator of the DNA damage checkpoint.Science 2002; 298: 1435–8.
  • DiTullio RA, Jr, Mochan TA, Verene M, Bartkova J, Sehested M, Bartek J, et al. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer.Nat Cell Biol 2002; 4: 998–1002.
  • Fernandez-Capetillo O, Chen H-T, Celeste A, Ward I, Romanienko PJ, Morales JC, et al. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.Nat Cell Biol 2002; 4: 993–7.
  • Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim S-T, et al. Convergence of the Fanconi anemia and Ataxia telangiectasia signaling pathways.Cell 2002; 109: 459–72.
  • D'Amours D, Jackson SP. The Mrell complex: at the crossroads of DNA repair and checkpoint signalling.Nat Rev Mol Cell Biol 2002; 3: 317–27.
  • Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, et al. MDC1 is required for the intra-S-phase DNA damage checkpoint.Nature 2003; 421: 952–6.
  • Lou Z, Minter-Dykhouse K, Wu X, Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.Nature 2003; 421: 957–61.
  • Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ. MDC1 is a mediator of the mammalian DNA damage checkpoint.Nature 2003; 421: 961–6.
  • Nigg EA. Mitotic kinases as regulators of cell division and its checkpoints.Nat Rev Mol Cell Biol 2001; 2: 21–32.
  • Mailand N, Podtelejnikov AV, Groth A, Mann M, Bartek J, Lukas J. Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability. EMBO y 2002; 21: 5911–20.
  • Smits VA, Klompmaker R, Arnaud L, Rijksen G, Nigg EA, Medema RH. Polo-like kinase-1 is a target of the DNA damage checkpoint.Nat Cell Biol 2000; 2: 672–6.
  • Venkitaraman AR. Cancer susceptibility and the functions of BRCA1 and BRCA2.Cell 2002; 108: 171–82.
  • Cortez D, Wang Y, Qin J, Elledge SJ. Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks.Science 1999; 286: 1162–6.
  • Lee JS, Collins KM, Brown AL, Lee CH, Chung JH. hCdsl-mediated phosphorylation of BRCA1 regulates the DNA damage response.Nature 2000; 404: 201–4.
  • Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, et al. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.Genes Dev 2000; 14: 2989–3002.
  • Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC. BRCA1 regulates the G2/M checkpoint by activating Chkl kinase upon DNA damage.Nat Genet 2002; 30: 285–9.
  • Musacchio A, Hardwick KG. The spindle checkpoint: structural insights into dynamic signalling.Nat Ren Mol Cell Biol 2002; 3: 731–41.
  • Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, et al. Mutations of mitotic checkpoint genes in human cancers.Nature 1998; 392: 300–3.

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