Reactive oxygen species and immune regulation

Abstract

Reactive oxygen species (ROS) is a kind of single electron reduction product of oxygen in vivo. Because they contain unpaired electrons, ROS has high chemical reactivity. Various researches of ROS are focused on DNA damage, cell apoptosis, oxidative stress. Actually, ROS is also closed related to immune regulation. Based on this, we review the research in immune regulated ROS production, regulation of ROS on inflammatory factors and inflammatory response, antigen presentation and macrophage polarization for better understanding of its role.

Keywords:

• Antigen presentation
• interleukin
• macrophage polarization
• reactive oxygen species
• TNF-α

Disclosure statement

The authors declare that they have no competing interests.

Additional information

Funding

The present study was funded by Outstanding Clinical Discipline Project of Shanghai Pudong (Grant No. PWYgy-2018-08) and Program for Medical Key Departments of Shanghai (Grant No. ZK2019A10).