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Pediatric Hematology and Oncology Volume 22, 2005 - Issue 5
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Brief Report

SEVERE NEUROTOXICITY, OTOTOXICITY AND NEPHROTOXICITY FOLLOWING HIGH-DOSE CISPLATIN AND AMIFOSTINE

Jairam Sastry Oncology Unit, The Children's Hospital at Westmead, and the Discipline of Paediatrics and Child Health at the University of Sydney, Sydney, NSW, Australia
, MD, MRCP, MRCPCH, &
Stewart J. Kellie Oncology Unit, The Children's Hospital at Westmead, and the Discipline of Paediatrics and Child Health at the University of Sydney, Sydney, NSW, Australia
, MB BS, FRACP
Pages 441-445 | Received 26 Jan 2005, Accepted 10 Mar 2005, Published online: 09 Jul 2009
 
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Abstract

Cisplatin in higher doses have been used routinely in the treatment of childhood tumours including neuroblastoma and germ cell tumors. Amifostine, a broad-spectrum cytoprotector of normal tissues, has been approved by U.S. Food and Drug Administration for use in patients receiving cisplatin. Such administration of amifostine has been reported to reduce cisplatin-related toxicities in some studies, but not all. The authors report a case of severe toxicity with cisplatin in a girl with epithelial cell carcinoma of the ovary despite the use of amifostine.

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