AUTOMATED RETICULOCYTE RESPONSE IS A GOOD PREDICTOR OF BONE-MARROW RECOVERY IN PEDIATRIC MALIGNANCIES

Reena Das Department of Paediatrics, Postgraduate Institute of Medical Education & Research, Chandigarh, India

, MD, Dip NB,

Ajay Rawal Department of Paediatrics, Postgraduate Institute of Medical Education & Research, Chandigarh, India

, MD,

Gurjeewan Garewal Department of Paediatrics, Postgraduate Institute of Medical Education & Research, Chandigarh, India

, MD,

R. K. Marwaha Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh, India

, MD &

Harpreet Vohra Department of Haematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India

, PhD

Abstract

The authors attempted to establish the benefits of flow cytometry-based reticulocyte analysis over absolute neutrophil count (ANC) recovery. Serial hemograms of 18 pediatric cases of hematologic malignancies were analyzed until day 35 of chemotherapy. Immature reticulocyte fraction (IRF) showed early recovery in 44.4% of cases compared to ANC. Since reticulocyte fractions are not influenced by infections, they are a better parameter of bone marrow regeneration than ANC. The study shows that IRF can act as a harbinger of regenerating bone marrow activity in patients with persistent neutropenia and guide the modulation of antibiotic strategies in these patients.

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AUTOMATED RETICULOCYTE RESPONSE IS A GOOD PREDICTOR OF BONE-MARROW RECOVERY IN PEDIATRIC MALIGNANCIES

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AUTOMATED RETICULOCYTE RESPONSE IS A GOOD PREDICTOR OF BONE-MARROW RECOVERY IN PEDIATRIC MALIGNANCIES

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