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Pediatric Hematology and Oncology Volume 24, 2007 - Issue 8
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Case Report

VENO-OCCLUSIVE DISEASE IN A CHILD WITH RHABDOMYOSARCOMA AFTER CONVENTIONAL CHEMOTHERAPY: Report of a Case and Review of the Literature

Emre Cecen Department of Pediatric Oncology, Dokuz Eylül University, Institute of Oncology, Izmir, Turkey
, MD,
Kamer Mutafoglu Uysal Department of Pediatric Oncology, Dokuz Eylül University, Institute of Oncology, Izmir, Turkey
, MD,
Aykan Ozguven Department of Pediatric Oncology, Dokuz Eylül University, Institute of Oncology, Izmir, Turkey
, MD,
Dilek Gunes Department of Pediatric Oncology, Dokuz Eylül University, Institute of Oncology, Izmir, Turkey
, MD,
Gulersu Irken Department of Pediatric Hematology, Dokuz Eylül University, Institute of Oncology, Izmir, Turkey
, MD &
Nur Olgun Department of Pediatric Oncology, Dokuz Eylül University School of Medicine, Izmir, Turkey
, MD
Pages 615-621 | Received 13 Feb 2007, Accepted 20 Jul 2007, Published online: 09 Jul 2009
 
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Abstract

Although veno-occlusive disease of the liver is a well-known complication of high-dose chemotherapy and bone marrow transplantation, it has rarely been observed in children who receive conventional chemotherapy. Most cases in the literature consists of children with Wilms tumor. It has been very uncommon in rabdomyosarcoma patients until recently, although they commonly receive similar anticancer agents. Here the authors report a 2-year-old boy with rhabdomyosarcoma who developed veno-occlusive disease while receiving VAC (vincristine, actinomycin D, cyclophosphamide) chemotherapy regimen according to the IRS-IV protocol. The patient gradually recovered during 2 weeks with supportive treatment only.

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