ANTIPHOSPHLIPIDS ANTIBODIES IN A 12-MONTH-OLD PRESENTING WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA

Abstract

A 12-month-old Caucasian female with a history of recurrent ear infections presented to the emergency room with petechiae, severe thrombocytopenia (4000/μL), and abnormally prolonged activated partial thromboplastin time. Further autoantibody investigation detected antinuclear antibodies, anti-double-stranded DNA, and antiphospholipid antibodies. Platelet count, in response to intravenous immunoglobulin infusion, increased to more than 100 × 10³ plt/μL. At 6-month follow-up, no positive autoantibodies were detected.

Keywords:

• antiphospholipid antibodies (APLA)
• antiphospholipid syndrome (APS)
• immune thrombocytopenic purpura (ITP)