METHOTREXATE RECHALLENGE FOLLOWING DELAYED CLEARANCE AND LIFE-THREATENING TOXICITY

Abstract

Life-threatening toxicity is often a contraindication for cytotoxic treatment. Many childhood malignancies have good outcomes with appropriate aggressive chemotherapy. It is not easy to decide whether to subject a child with a good prognostic tumor to a drug that has previously caused significant toxicity. One such situation is documented in this report.

Keywords:

• Methotrexate
• toxicity