ANAPHYLACTOID REACTION TO HIGH-DOSE METHOTREXATE AND RE-ADMINISTRATION AFTER A SUCCESSFUL DESENSITIZATION

Teresa Caldeira Department of Paediatrics, Centro Hospitalar Vila Nova de Gaia, Vila Nova de Gaia, Portugal

Vitor Costa Department of Medical Oncology, Division of Paediatric Hematology/Oncology, Portuguese Institute of Oncology–Porto, Porto, Portugal

Isabel Silva Department of Medical Oncology, Division of Paediatric Hematology/Oncology, Portuguese Institute of Oncology–Porto, Porto, Portugal

Tereza Oliva Department of Medical Oncology, Division of Paediatric Hematology/Oncology, Portuguese Institute of Oncology–Porto, Porto, Portugal

Lucília Norton Department of Medical Oncology, Division of Paediatric Hematology/Oncology, Portuguese Institute of Oncology–Porto, Porto, Portugal

Abstract

Methotrexate (MTX) is an antimetabolite with a major role in the treatment of acute lymphoblastic leukaemia (ALL). The authors report the management of a 9-year-old boy who developed an anaphylactoid reaction to high-dose MTX infusion, after a first challenge with intrathecal administration, during induction therapy for ALL. A desensitization protocol was followed and MTX tolerance has been successfully achieved, allowing this patient to complete the needed chemotherapy.

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ANAPHYLACTOID REACTION TO HIGH-DOSE METHOTREXATE AND RE-ADMINISTRATION AFTER A SUCCESSFUL DESENSITIZATION

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ANAPHYLACTOID REACTION TO HIGH-DOSE METHOTREXATE AND RE-ADMINISTRATION AFTER A SUCCESSFUL DESENSITIZATION

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