RELAPSE OF PRIMITIVE MEDIASTINAL LYMPHOMA AS A MYELOID MASS FOLLOWING BEAM AUTOLOGOUS TRANSPLANT AND SUBSEQUENT REFRACTORINESS TO MATCHED UNRELATED UMBILICAL CORD BLOOD ALLOGRAFT

Parameswaran Anoop Department of Pediatric Hemato-Oncology, Royal Marsden Hospital, Surrey, UK

, MRCPCH,

Donna L. Lancaster Department of Pediatric Hemato-Oncology, Royal Marsden Hospital, Surrey, UK

, MRCPCH,

Mark E. Ethell Department of Pediatric Hemato-Oncology, Royal Marsden Hospital, Surrey, UK

, FRCPath,

Mike N. Potter Department of Pediatric Hemato-Oncology, Royal Marsden Hospital, Surrey, UK

, FRCPath &

Andrew Wotherspoon Department of Pediatric Hemato-Oncology, Royal Marsden Hospital, Surrey, UK

, FRCPath

Abstract

Outlining the treatment for an unclassifiable lymphoid malignancy is often difficult. A highly undifferentiated lymphomatous mass that relapsed in spite of intense chemotherapy and autologous transplant is reported. At relapse, there was differentiation into myeloid lineage. Though remission was achieved with AML-type reinduction chemotherapy, the mass recurred post allogenic cord blood stem cell transplant.

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RELAPSE OF PRIMITIVE MEDIASTINAL LYMPHOMA AS A MYELOID MASS FOLLOWING BEAM AUTOLOGOUS TRANSPLANT AND SUBSEQUENT REFRACTORINESS TO MATCHED UNRELATED UMBILICAL CORD BLOOD ALLOGRAFT

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RELAPSE OF PRIMITIVE MEDIASTINAL LYMPHOMA AS A MYELOID MASS FOLLOWING BEAM AUTOLOGOUS TRANSPLANT AND SUBSEQUENT REFRACTORINESS TO MATCHED UNRELATED UMBILICAL CORD BLOOD ALLOGRAFT

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