Lipid Apheresis to Manage Severe Hypertriglyceridemia during Induction Therapy in a Child with Acute Lymphoblastic Leukemia

Abstract

PEG asparaginase is an important and established drug in the treatment of pediatric acute lymphoblastic leukemia (ALL). Severe hypertriglyceridemia is a rare complication of PEG asparaginase in combination with glucocorticoids. We report a case of excessive hypertriglyceridemia in a child during ALL induction therapy successfully treated by lipid apheresis and give a literature review on the management of hypertriglyceridemia in children treated for ALL.

Keywords:

• Acute lymphoblastic leukemia
• asparaginase
• hypertriglyceridemia
• hyperlipidemia
• lipid apheresis

Acknowledgments

We thank the patient and his family for consent to the publication.

Authorship contribution

J.S. performed the lipid apheresis. C.M. and C.F. wrote the manuscript. All authors treated the patient and contributed to writing the manuscript.

Disclosure statement

The authors declare no conflicts of interest.