CONTINUOUS INFUSION OF VON WILLEBRAND FACTOR AND FACTOR VIII AFTER ELECTIVE HEART SURGERY IN A 12-YEAR-OLD GIRL WITH VON WILLEBRAND DISEASE TYPE 3

Abstract

The continuous infusion of von Willebrand factor (VWF) in a 12-year-old girl with type 3 von Willebrand disease is described. The patient had elective heart surgery with cardiopulmonary bypass for closure of her atrial septum defect. The surgical procedure lasted 3 h. A presurgical bolus followed by a postoperative continuous infusion of factor VIII/VWF concentrates was administered. During the continuous infusion of clotting factors, stable plasma levels of hemostasis and avoidance of dangerously low levels of factor concentrates were achieved. No peri- or postsurgical complications occurred. Continuous infusion of clotting factors allows constant and hemostatic factor concentrations to be maintained with the possibility of dose titration and adjustment.

• Continuous Infusion
• Von Willebrand Disease Type 3
• Von Willebrand Factor
• Concentrate