Resveratrol restores the level of key inflammatory cytokines and RANKL/OPG ratio in the femur of rat osteoporosis model

ABSTRACT

Resveratrol’s effect on bone mineral density (BMD) and expression of cytokines in ovariectomized rats (postmenopausal osteoporosis model) was studied. The study was conducted on 3-month-old Sprague-Dawley rats that were (a) sham-operated, (b) ovariectomized, (c) ovariectomized and treated with β-estradiol (487.5 µg/kg weight/day), and (d) ovariectomized and treated with resveratrol (625 µg/Kg body weight/day). The treatment was for 4 weeks. After sacrifice BMD and gene expression (RANKL, OPG, IL-23, and IL-17A, IL-1β, and TNFα) were measured in tibia and femur respectively. Resveratrol could restore RANKL/OPG ratio, slightly increase BMD, and moderately but significantly reduce IL-23, IL-17A, IL-1β, and TNF-α cytokine expression levels.

KEYWORDS:

• Inflammatory cytokines
• menopause
• osteoporosis
• RANKL/OPG
• resveratrol

Disclosure statement

The author declares no conflicts of interest.

Declaration

The manuscript has not been published elsewhere and also it has not been submitted simultaneously for publication elsewhere.

Additional information

Funding

This work was supported by generous funding from the Department of Biotechnology (DBT), New Delhi, India, to perform the experiments (BT/PR7761/MED/14/1055/2006).